Antidepressants Cymbalta (Duloxetine) What are generics? Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.

 Prozac (Generic)

Cymbalta is one of the most effective antidepressants used for the treatment of the major depressive disorder, generalized anxiety disorder, and neuropathic pain. The active ingredient of Cymbalta is called Duloxetine. This drug is an inhibitor of the reuptake of serotonin and norepinephrine, while it has a weak inhibitory effect on the reuptake of dopamine. Thus, the principle of its work is based on the increase of noradrenergic and serotonergic neurotransmission in the central nervous system.

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The drug Cymbalta (Duloxetine) should be taken orally, swallowing whole capsules, regardless of food intake. Crushing/chewing capsules, mixing them with liquids, and adding them to food (this will destroy the enteric shell of the capsule) are not allowed.

The initial dose is 60 mg/day and, if necessary, can be increased up to a maximum of 120 mg/day. In this case, the dose should be divided into two doses.

For patients suffering from severe renal failure (with a QC less than 30 ml/min), the initial dosage of Cymbalta is 30 mg/day. People suffering from violations of the functioning of the liver should reduce the initial dose of duloxetine or reduce the frequency of intake.
Such side effects as sleep disturbance (both drowsiness and insomnia), dizziness (excluding vertigo), headache, nausea, dry mouth, and constipation are most commonly observed. Dizziness, nausea, and headache were noted as frequent adverse effects when Cymbalta (Duloxetine)was withdrawn.

Effect on the concentration of glucose in patients with painful form of diabetic neuropathy: there may be a slight increase in fasting blood glucose in the presence of duloxetine.
Cymbalta (Duloxetine) should not be used in the case of the hypersensitivity to the drug, simultaneous use with monoamine oxidase inhibitors (MAOI), and uncompensated angle-closure glaucoma Cymbalta should be used with caution with an aggravation of the manic/hypomanic state, epileptic seizures, mydriasis, impaired liver or kidney function, and with the likelihood of suicide attempts.

Given the effects of duloxetine on the central nervous system (CNS), caution should be exercised when taking duloxetine in combination with other centrally acting drugs or when replacing it with other drugs, including drugs with a similar mechanism of action.


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